Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice

Table 10

Changes in the gastrocnemius muscle immunohistomorphometrical analysis in mice with NTX-induced muscle atrophy.

Antibody	Groups
	Controls		Reference	EESF treated mice (mg/kg)
	Sham	NTX	Oxymetholone	500	250	125
Caspase-3 (fibers/mm^2)	3.70 ± 1.49	40.70 ± 5.85^c	19.40 ± 4.09^cd	19.60 ± 2.50^cd	23.10 ± 3.90^cd	31.40 ± 3.75^cd
PARP (fibers/mm^2)	6.10 ± 1.60	73.50 ± 11.33^c	44.60 ± 11.17^cd	43.70 ± 12.27^cd	53.90 ± 10.50^cd	60.80 ± 6.43^cd
NT (fibers/mm^2)	8.70 ± 2.00	66.70 ± 14.01^c	30.60 ± 11.09^cd	33.50 ± 11.42^cd	44.90 ± 10.48^cd	50.86 ± 11.19^ce
4-HNE (fibers/mm^2)	5.70 ± 2.16	74.60 ± 12.38^c	42.90 ± 10.34^cd	42.50 ± 12.25^cd	52.40 ± 10.46^cd	61.30 ± 10.79^ce
iNOS (fibers/mm^2)	6.40 ± 2.01	71.90 ± 12.13^a	36.30 ± 11.47^ab	35.90 ± 10.35^ab	45.70 ± 10.53^ab	57.00 ± 11.81^ab
COX-2 (cells/mm^2)	10.80 ± 4.78	259.80 ± 30.90^c	194.10 ± 30.50^cd	154.20 ± 25.18^cd	185.10 ± 20.63^cd	226.20 ± 25.13^ce
TNF-α (cells/mm^2)	32.40 ± 13.20	231.20 ± 41.87^a	171.10 ± 18.39^ab	148.20 ± 29.95^ab	183.70 ± 22.07^ab	191.30 ± 21.54^ab
Myostatin (fibers/mm^2)	3.30 ± 1.34	45.30 ± 10.65^c	17.40 ± 4.27^cd	18.50 ± 6.95^cd	27.20 ± 5.12^cd	32.10 ± 10.92^cd

Values are expressed as mean ± S.D. of 10 mice.
^a as compared with sham control mice by the LSD test.
^b as compared with NTX control mice by the LSD test.
^c as compared with sham control mice by the MW test.
^d and ^e as compared with NTX control mice by the MW test.