Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice
Table 10
Changes in the gastrocnemius muscle immunohistomorphometrical analysis in mice with NTX-induced muscle atrophy.
Antibody
Groups
Controls
Reference
EESF treated mice (mg/kg)
Sham
NTX
Oxymetholone
500
250
125
Caspase-3 (fibers/mm2)
3.70 ± 1.49
40.70 ± 5.85c
19.40 ± 4.09cd
19.60 ± 2.50cd
23.10 ± 3.90cd
31.40 ± 3.75cd
PARP (fibers/mm2)
6.10 ± 1.60
73.50 ± 11.33c
44.60 ± 11.17cd
43.70 ± 12.27cd
53.90 ± 10.50cd
60.80 ± 6.43cd
NT (fibers/mm2)
8.70 ± 2.00
66.70 ± 14.01c
30.60 ± 11.09cd
33.50 ± 11.42cd
44.90 ± 10.48cd
50.86 ± 11.19ce
4-HNE (fibers/mm2)
5.70 ± 2.16
74.60 ± 12.38c
42.90 ± 10.34cd
42.50 ± 12.25cd
52.40 ± 10.46cd
61.30 ± 10.79ce
iNOS (fibers/mm2)
6.40 ± 2.01
71.90 ± 12.13a
36.30 ± 11.47ab
35.90 ± 10.35ab
45.70 ± 10.53ab
57.00 ± 11.81ab
COX-2 (cells/mm2)
10.80 ± 4.78
259.80 ± 30.90c
194.10 ± 30.50cd
154.20 ± 25.18cd
185.10 ± 20.63cd
226.20 ± 25.13ce
TNF-α (cells/mm2)
32.40 ± 13.20
231.20 ± 41.87a
171.10 ± 18.39ab
148.20 ± 29.95ab
183.70 ± 22.07ab
191.30 ± 21.54ab
Myostatin (fibers/mm2)
3.30 ± 1.34
45.30 ± 10.65c
17.40 ± 4.27cd
18.50 ± 6.95cd
27.20 ± 5.12cd
32.10 ± 10.92cd
Values are expressed as mean ± S.D. of 10 mice. a as compared with sham control mice by the LSD test. b as compared with NTX control mice by the LSD test. c as compared with sham control mice by the MW test. d and e as compared with NTX control mice by the MW test.