Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice

Table 8

Changes in the gastrocnemius muscle mRNA expression levels in mice with NTX-induced muscle atrophy.

Targets	Groups
	Controls		Reference	EESF treated mice (mg/kg)
	Sham	NTX	Oxymetholone	500	250	125
Atrogin-1	1.05 ± 0.11	4.41 ± 1.06^d	2.24 ± 0.28^df	2.29 ± 0.59^df	2.85 ± 0.61^df	3.19 ± 0.78^df
MuRF 1	1.04 ± 0.13	3.81 ± 0.69^a	2.21 ± 0.43^ac	2.20 ± 0.55^ac	2.37 ± 0.42^ac	2.95 ± 0.61^ac
PI3K p85α	0.95 ± 0.11	0.74 ± 0.12^d	1.54 ± 0.64^ef	1.58 ± 0.73^f	1.05 ± 0.13^f	0.93 ± 0.12^f
Akt 1	0.97 ± 0.11	0.60 ± 0.18^a	0.88 ± 0.14^c	0.88 ± 0.10^c	0.80 ± 0.10^ac	0.78 ± 0.10^ac
Adenosine A1R	0.98 ± 0.12	0.57 ± 0.10^a	0.97 ± 0.13^c	0.98 ± 0.14^c	0.84 ± 0.15^bc	0.79 ± 0.11^ac
TRPV4	0.99 ± 0.09	0.45 ± 0.12^a	0.77 ± 0.13^ac	0.77 ± 0.11^ac	0.69 ± 0.11^ac	0.64 ± 0.12^ac
Myostatin	1.00 ± 0.11	7.65 ± 1.53^d	3.25 ± 0.99^df	3.20 ± 0.71^df	4.16 ± 0.78^df	5.36 ± 0.49^df
SIRT1	1.03 ± 0.14	6.83 ± 1.07^d	3.80 ± 0.81^df	3.83 ± 0.95^df	4.35 ± 1.10^df	5.22 ± 0.79^df

Values are expressed as mean ± S.D. of six mice, relative expressions/18s ribosomal RNA.
^a and ^b as compared with intact control mice by the LSD test.
^c as compared with NTX control mice by the LSD test.
^d and ^e as compared with intact control mice by the LSD test.
^f as compared with NTX control mice by the LSD test.