Ginkgolide B Inhibits JAM-A, Cx43, and VE-Cadherin Expression and Reduces Monocyte Transmigration in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells

Figure 4

Ginkgolide B reduces monocyte transmigration in ox-LDL-treated HUVECs. (a) Ginkgolide B reduced monocyte transmigration in ox-LDL-treated endothelial cells. (b) HUVECs were treated with si JAM-A for 48 h. Monocyte transmigration was detected in ox-LDL-treated and si JAM-A-transfected cells. (c) Monocyte transmigration was detected in ox-LDL-treated and si Cx43-transfected cells. (d) Monocyte transmigration was detected in ox-LDL-treated and si VE-cadherin-transfected cells. The data were obtained from three independent experiments. , ox-LDL-treated cells versus non-ox-LDL-treated cells; and , ox-LDL-treated cells versus ginkgolide B-treated cells.

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