The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential

<div>Biosynthesis pathways of endogenous H<sub>2</sub>S. Cystathionine-<svg height="12.6917pt" id="M4" style="vertical-align:-3.40337pt" version="1.1" viewbox="-0.0498162 -9.28833 7.75923 12.6917" width="7.75923pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M563 583C563 664 501 710 433 710C381 710 334 692 285 648C212 582 178 506 149 350L74 -56C49 -190 36 -222 24 -226L30 -257C52 -256 95 -247 121 -229C131 -222 134 -206 165 -21L219 303C254 510 296 665 397 665C447 665 481 626 481 572C481 512 446 457 390 420C367 405 351 400 323 397L302 349C398 338 466 285 466 197C466 117 419 45 306 45C268 45 224 59 198 74L186 50C197 20 228 -14 274 -14C318 -14 359 3 401 26C478 68 554 144 554 225C554 322 493 367 412 396C490 446 563 500 563 583Z" id="g50-224"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g></svg>-synthase (CBS) and cystathionine-<svg height="9.4034pt" id="M5" style="vertical-align:-3.40335pt" version="1.1" viewbox="-0.0498162 -6.00005 6.84582 9.4034" width="6.84582pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M493 373C493 420 472 451 445 451C421 451 400 435 400 410C400 404 402 400 406 394S417 371 417 350C417 259 317 128 256 55H254C260 126 256 262 238 340C219 424 194 451 163 451C128 451 78 413 24 329L52 302C89 353 106 370 121 370C129 370 137 363 147 336C186 231 196 73 184 -16C152 -88 120 -192 112 -238L130 -257C157 -253 213 -227 231 -213C231 -187 234 -77 240 -23C251 -6 277 30 309 69C424 208 493 299 493 373Z" id="g50-225"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="517" vert-adv-y="517"></glyph.data></g></svg>-lyase (CSE) use L-cysteine as a substrate to produce H<sub>2</sub>S. However, 3-mercaptopyruvate sulfurtransferase (3-MST) uses 3-mercaptopyruvate (3-MP) as a substrate to form H<sub>2</sub>S. 3-MP is produced by cysteine aminotransferase (CAT) from L-cysteine in the presence of <svg height="6.20645pt" id="M6" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -6.00005 7.69399 6.20645" width="7.69399pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M558 106L533 129C501 84 476 67 464 67C446 67 435 116 414 239C457 297 508 367 550 440L539 451L484 438C458 390 429 338 404 300H402C375 407 351 451 285 451C168 451 24 312 24 153C24 56 66 -12 132 -12C206 -12 284 64 345 156H347C367 24 386 -12 422 -12C457 -12 503 7 558 106ZM338 206C272 99 215 56 173 56C140 56 116 96 116 170C116 303 194 405 255 405C304 405 324 299 338 206Z" id="g50-223"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="582" vert-adv-y="582"></glyph.data></g></svg>-keto glutarate (<svg height="6.20645pt" id="M7" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -6.00005 7.69399 6.20645" width="7.69399pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M558 106L533 129C501 84 476 67 464 67C446 67 435 116 414 239C457 297 508 367 550 440L539 451L484 438C458 390 429 338 404 300H402C375 407 351 451 285 451C168 451 24 312 24 153C24 56 66 -12 132 -12C206 -12 284 64 345 156H347C367 24 386 -12 422 -12C457 -12 503 7 558 106ZM338 206C272 99 215 56 173 56C140 56 116 96 116 170C116 303 194 405 255 405C304 405 324 299 338 206Z" id="g50-223"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="582" vert-adv-y="582"></glyph.data></g></svg>-KG); on the other hand, it is also produced by D-amino acid oxidase (DAO) from D-cysteine.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential 