Sesquiterpene Lactones Inhibit Advanced Oxidation Protein Product-Induced MCP-1 Expression in Podocytes via an IKK/NF-κB-Dependent Mechanism

Figure 2

AOPPs stimulation increased the expression of MCP-1 in cultured podocytes. Podocytes were incubated with the indicated concentration of AOPPs for 24 h or 200 μg/mL of AOPPs for the indicated time and subjected to MCP-1 mRNA and protein expression analysis. AOPP treatment increased the expression of MCP-1 at both the mRNA (c, d) and protein levels (a, b) in a dose- and time-dependent manner. Data are expressed as the means ± SD of three independent experiments. ANOVA, , , and versus CON. CON, untreated cells; MSA, mouse serum albumin.

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