Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice

Figure 1

Intervention of FO+ALA-PS ameliorated atherosclerosis in HFD diet-fed mice. Photomicrographs of representative Oil-Red O stained aortas of mice in control, HFD, FO, and ALA-PS groups (a). Quantitative analysis of the atherosclerotic lesion aortas of mice. The lesion area was measured as the percentage of aortic luminal area covered by atherosclerotic lesions. Values are given as mean ± standard deviation of the mean (). versus the control; versus the HFD group; versus the FO group (b). Representative images of cross-sections taken of the aortic sinuses obtained from mice in control, HFD, FO, and ALA-PS groups. The sections of aortic sinuses were stained with Oil-Red O (magnification ×40) for lipid deposition (red) and cross-stained with hematoxylin (blue) (c). Quantitative analysis of the atherosclerotic lesions in aortic sinuses of mice. The lesion area was measured as the percentage of aortic luminal area covered by atherosclerotic lesions. Values are given as mean ± standard deviation of the mean (). versus the control; versus the HFD group; versus the FO group (d).

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