Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice

Table 2

Effects of FO+ALA-PS on lipid profiles in mice.

	Groups
	Control	HFD	FO	FO+ALA-PS
Serum TC (mmol/L)	1.72 ± 0.24	20.77 ± 5.00^a	16.04 ± 4.59^a	11.33 ± 3.15^abc
Serum TG (mmol/L)	0.91 ± 0.15	2.27 ± 0.40^a	1.83 ± 0.42^ab	1.39 ± 0.41^abc
Serum LDL-C (mmol/L)	0.31 ± 0.12	12.16 ± 3.11^a	10.24 ± 2.32^a	4.17 ± 1.35^abc
Serum HDL-C (mmol/L)	1.01 ± 0.14	0.26 ± 0.12^a	0.45 ± 0.23^ab	0.60 ± 0.16^abc
Liver TC (mg/g)	2.54 ± 0.19	4.09 ± 0.75^a	3.52 ± 0.38^a	2.55 ± 0.24^bc
Liver TG (mg/g)	26.47 ± 6.40	64.04 ± 18.49^a	40.81 ± 7.63^ab	30.80 ± 6.21^bc

Forty-two apoE KO mice were randomly divided into 3 groups on average, namely, HFD, FO, and FO+ALA-PS. Fourteen wild type C57BL/6 mice were divided into control group. Values are given as means ± SD (). ^a < 0.05 versus the control; ^b < 0.05 versus the HFD group; ^c < 0.05 versus the FO group. HFD: high fat diet; FO: HFD + 5% flaxseed oil; FO + ALA-PS: HFD + 2.7% flaxseed oil + 3.3% flaxseed oil ester of plant sterol.