Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

Table 1

Major sites of neuronal damage and potential therapeutic agents indicating their sites of neuroprotective action.

Important sites for protection in neuronal stress
	Type of neuronal stress	Neuroprotective agent
1	Excitotoxicity	DETC-MeSO, memantine, or taurine
2	Calcium overload	Taurine or preconditioning mechanisms
3	Increases in oxidative stress	Taurine or preconditioning mechanisms
4	Apoptosis	Taurine, DETC-MeSO, or preconditioning mechanisms
5	Endoplasmic reticulum stress	Taurine or DETC-MeSO