Oxidative Stress during the Progression of <i>β</i>-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

<div>Senile plaques in Tg neocortex. (a) Congo Red staining, observed under polarized light. Small, birefringent structures are first detected at 9 months (A), while larger plaques are seen at 18 months ((B) and (C)). Scale bars A and B, 30 <i>μ</i>m; C, 15 <i>μ</i>m. (b) Neocortical areas of 18-month-old Tg mice, showing large senile plaques, after IHC for NeuN (D), GFAP (E), and Iba1 (F). Glial cells, but not neuronal cell bodies, are seen within the aggregates. Scale bars, 15 <i>μ</i>m.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2: Oxidative Stress during the Progression of <i>β</i>-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease 

Oxidative Medicine and Cellular Longevity

Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

Figure 2