Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

Figure 9

Peroxisomal protein levels and distribution in the neocortex of WT and Tg mice. PMP70 expression showing downregulation at 6 months, as assessed by WB densitometry (a) and IHC distribution (b). Enhancement of PMP70 expression is observed in 9-month-old Tg neurons. Scale bars, 40 μm. (c) Densitometric analyses of WB for CAT, Pex14p, AOX, and THL performed on neocortical protein extracts from 3-, 6-, 9-, 12-, and 18-month-old mice. Significant downregulation of CAT in 6-month-old Tg neocortex is detected. Values are expressed as mean ± SD. ; ; .

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