Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel
3-Aminotriazole (3-AT) mimics the effect of AGEs on ENaC . (a) The representative single-channel currents of ENaC recorded under control conditions (basolateral 200 μg/mL BSA for 24 h; top), after apical 20 mM 3-AT treatment for 30 min (middle), or after 24 h AGE treatment followed by treatment with apical 20 mM 3-AT for 30 min (bottom). (b) Summary plots show that ENaC was significantly, respectively, increased after 20 mM 3-AT treatment ( for control and for 3-AT group; indicates compared to control). Addition of 3-AT to AGEs did not further increase ENaC compared to 3-AT alone ( for AGEs + 3-AT group; ).
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