Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel
TEMPOL abolishes the effects of AGEs and 3-AT on ENaC activity. (a) ROS extraction by 250 μM TEMPOL significantly decreased ENaC ( paired experiments; represents ). (b) and (c) TEMPOL significantly reduced ENaC activity in cells pretreated with 200 μg/mL AGEs (b) or in the cells pretreated with 20 mM 3-AT (c) ( paired experiments; represents ).
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