Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel

Figure 6

AGEs-induced aberrant activation of ENaC in A6 cells exerts “metabolic memory.” (a) Representative ENaC single-channel currents recorded either from an A6 cell in the presence of basolateral 200 μg/mL BSA or from an A6 cell after removal of 200 μg/mL BSA for 72 h. (b) Representative ENaC single-channel currents recorded either from an A6 cell in the presence of basolateral 200 μg/mL AGEs from an A6 cell after removal of 200 μg/mL AGEs for 72 h. (c) Summarized bar graph shows that basolateral AGEs significantly increased ENaC and the ENaC remained at the same levels after removal of AGEs for 72 h (–10; and #, resp., indicate ).

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(b)

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