Elevation of HO-1 Expression Mitigates Intestinal Ischemia-Reperfusion Injury and Restores Tight Junction Function in a Rat Liver Transplantation Model

Figure 1

Histopathologic changes in intestines after orthotopic autologous liver transplantation (OALT). HE-stained intestine sections collected at 8 h after reperfusion from the sham, OALT + saline, OALT + hemin, and OALT + ZnPP groups (a) (×200). Rats were intraperitoneally injected with saline, hemin (30 mg/kg), and ZnPP (20 mg/kg) separately in corresponding groups 24 h before operation and then received celiotomy and vascular separation with or without OALT. Intestinal mucosa injury was graded by Chiu’s score (b). The data were presented as the mean ± SD, –6 per group. , , one-way ANOVA with Tukey test.

(a)

(b)