Soluble Receptor for Advanced Glycation End Product Ameliorates Chronic Intermittent Hypoxia Induced Renal Injury, Inflammation, and Apoptosis via P38/JNK Signaling Pathways
Effect of sRAGE on CIH-induced histological damage and renal dysfunction. (a) Representative kidney sections from normal air (NA) group, CIH group, CIH+sRAGE group, and negative control (NA+sRAGE) group are stained by H&E (scale bar: 50 μm). In light microscopic examination, tubular degeneration, interstitial neutrophil infiltration, and massive desquamation of renal epithelium are more remarkable in the kidney tissues of CIH rats compared to NA group, while pretreatment of sRAGE apparently shows almost normal tubules and mild dilatation of tubular lumen absence of severe inflammatory infiltrations. (b) Sections are graded based on the 0–5 Jablonski grading scale averaging the values from 10 fields per kidney under microscopy. Renal function is determined by serum creatinine (c) and BUN (d). Data are presented as the mean ± SEM. , ; /group.
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