Soluble Receptor for Advanced Glycation End Product Ameliorates Chronic Intermittent Hypoxia Induced Renal Injury, Inflammation, and Apoptosis via P38/JNK Signaling Pathways
Effect of sRAGE on renal tubular endothelial cell apoptosis. (a) Representative immunofluorescence staining for CD31 (green), TUNEL (red), DAPI (blue), and the merged pictures from kidney tissues of each group. The scale bars represent 50 μm. (b) Quantitative assessment of the percentage of apoptosis by counting the TUNEL+/DAPI+ cells in 10 random fields (100x) for each section. (c) Western blots analysis of Bcl-2 and Bax protein in comparison with GAPDH used as a loading control. (d) Representative bar diagram showing quantitative relative levels of Bcl-2 and Bax in NA, CIH, CIH+sRAGE, and NA plus sRAGE treated groups. Data are presented as the mean ± SEM. NS: no significance. , ; /group.
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