Oxidative Medicine and Cellular Longevity / 2016 / Article / Fig 3

Research Article

Soluble Receptor for Advanced Glycation End Product Ameliorates Chronic Intermittent Hypoxia Induced Renal Injury, Inflammation, and Apoptosis via P38/JNK Signaling Pathways

Figure 3

Representative immunohistochemistry of renal cortex (the top panel including glomeruli and proximal tubule) and medulla (the bottom panel including peritubular capillaries and distal tubule) for localization of HMGB1 (scale bar: 50 μm). HMGB1 is abundant in cytoplasmic renal tubules of CIH group, compared with nuclear patterns of HMGB1 in NA group. sRAGE gradually attenuates HMGB1 cytoplasmic deposition, intraluminal infiltration, and nuclear staining in expanded renal tubules.

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