Tanshinol Rescues the Impaired Bone Formation Elicited by Glucocorticoid Involved in KLF15 Pathway

Figure 1

Tanshinol maintains bone microarchitecture and biomechanical properties. Rats were treated with distilled water (Con), prednisone (GC, 5 mg/kg·d), GC plus tanshinol (GC + Tan, 16 mg/kg·d), and GC plus resveratrol (GC + Res, 5 mg/kg·d) for 14 weeks. The following measurements were carried out. (a) Micro-CT reconstruction of the trabecular part of proximal femur of rats. (b) Microarchitectural parameters of proximal femoral spongiosa were measured by Micro-CT machine. (c) von Kossa staining of undecalcified sections of proximal tibia spongiosa of rats. (d) Biomechanics characteristics of femur were determined by three-point bending assay. Data are given as mean ± SD (). versus normal control (Con); versus GC treatment (GC).

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