Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Table 3

Potential medications that target oxidative stress in patients after hemorrhagic stroke.

Drug name	Clinical trials	Different types of intracerebral hemorrhage	Action mechanism	Outcome	References
NXY-059	NCT00075959 (CHANT)	ICH	Free radical-trapping agent	No benefit	[176]
Deferoxamine mesylate	NCT01662895 (Hi-Def)	ICH	Iron-chelator	Phase II clinical trial	[177]
Hydrogen-rich fluid	UMIN000014696	SAH	Delayed cerebral ischemia and cerebral vasospasm	Ongoing	[160]
Edaravone	—	SAH	Free radical scavenger	Preliminary	[178]
Simvastatin	NCT01077206; ISRCTN75948817	SAH	Lipid-lowering therapy	No benefit	[179, 180]
Lipid-lowering medication	NCT00226096 and NCT00716079 (INTERACT)	ICH	Lipid-lowering therapy	No benefit	[181]
Statin	NCT00221104	SAH	Lipid-lowering therapy	No benefit	[182]

ICH, intracranial hemorrhage; SAH, subarachnoid hemorrhage.