Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans

Table 3

Side effects of oral administration of ME. The subjects were asked to report the side effects after oral administration of ME at each visit. The number of episodes of each side effect prior to and after double doses was collected and calculated as the percentage of the total episodes of 110 (11 participants × 10 visits).

Symptom	Before (single dose)		After (double doses)
	Number of episodes	%	Number of episodes	%
Tiredness/sleepiness	4	3.6	0	0.0
Constipation	4	3.6	1	0.9
Dry throat	2	1.8	3	2.7
Headache	1	0.9	4	3.6
Flu-like symptoms	2	1.8	0	0.0
Abnormal stool	4	3.6	0	0.0
Abdominal discomfort	3	2.7	0	0.0
Cough	2	1.8	0	0.0
Weight loss	2	1.8	2	1.8
Nasal congestion	2	1.8	0	0.0
Abdominal bloating	2	1.8	1	0.9
Dizziness	1	0.9	0	0.0
Salivation	1	0.9	0	0.0
Nausea/vomiting	1	0.9	1	0.9
Diarrhea	1	0.9	1	0.9
Skin rash	1	0.9	0	0.0
Abnormal urination	1	0.9	0	0.0
Malaise	1	0.9	0	0.0