Table 3: Side effects of oral administration of ME. The subjects were asked to report the side effects after oral administration of ME at each visit. The number of episodes of each side effect prior to and after double doses was collected and calculated as the percentage of the total episodes of 110 (11 participants × 10 visits).

SymptomBefore (single dose)After (double doses)
Number of episodes%Number of episodes%

Tiredness/sleepiness43.600.0
Constipation43.610.9
Dry throat21.832.7
Headache10.943.6
Flu-like symptoms21.800.0
Abnormal stool43.600.0
Abdominal discomfort32.700.0
Cough21.800.0
Weight loss21.821.8
Nasal congestion21.800.0
Abdominal bloating21.810.9
Dizziness10.900.0
Salivation10.900.0
Nausea/vomiting10.910.9
Diarrhea10.910.9
Skin rash10.900.0
Abnormal urination10.900.0
Malaise10.900.0