Research Article
A Genetic Biomarker of Oxidative Stress, the Paraoxonase-1 Q192R Gene Variant, Associates with Cardiomyopathy in CKD: A Longitudinal Study
Table 2
Unadjusted and adjusted linear regression models of LVMI and LVEF (cross-sectional analysis).
| (a) LVMI model |
| | Variables (unit of increase) | Unadjusted model | Adjusted model | | b (95% CI) | β | P | (95% CI) | β | P |
| | Q192R polymorphism (one risk allele increase) | 17.06 (6.74 to 27.39) | 0.22 | 0.001 | 13.30 (3.43 to 23.17) | 0.17 | 0.008 | | HDL (1 mg/dL) | | | | −0.45 (−0.93 to 0.03) | −0.12 | 0.07 | | eGFR MDRD186 (1 mL/min/1.73 m2) | | | | −0.47 (−0.68 to −0.27) | −0.30 | <0.001 |
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| (b) LVEF model |
| | Variables (unit of increase) | Unadjusted model | Adjusted model | | b (95% CI) | β | P | (95% CI) | β | P |
| | Q192R polymorphism (one risk allele increase) | −3.12 (−5.12 to −1.11) | −0.21 | 0.002 | −2.91 (−4.92 to −0.91) | −0.20 | 0.005 | | HDL (1 mg/dL) | | | | 0.13 (0.03 to 0.23) | 0.18 | 0.01 | | eGFR MDRD186 (1 mL/min/1.73 m2) | | | | −0.02 (−0.06 to 0.02) | −0.06 | 0.39 |
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Data are expressed as unstandardized regression coefficient (b) and 95% confidence interval, standardized regression coefficient (β), and P value.
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