A Genetic Biomarker of Oxidative Stress, the Paraoxonase-1 Q192R Gene Variant, Associates with Cardiomyopathy in CKD: A Longitudinal Study

Table 3

Unadjusted and adjusted linear mixed models of LVMI and LVEF through follow-up (longitudinal analysis).

(a) LVMI model

Variables (units of increase)	Model 1 (unadjusted)		Model 2
	b	P value	b	P value
PON1 (Q192R)	13.40 (4.17 to 22.62)	0.005	9.24 (0.51 to 17.96)	0.04
HDL (1 mg/dL)			−0.44 (−0.86 to −0.02)	0.04
eGFR MDRD186 (1 mL/min/1.73 m^2)			−0.46 (−0.64 to −0.28)	<0.001

(b) LVEF model

Variables (units of increase)	Model 1 (unadjusted)		Model 2
	b	P value	b	P value
PON1 (Q192R)	−2.96; (−4.62 to −1.29)	0.001	−2.84 (−4.54 to −1.15)	0.001
HDL (1 mg/dL)			0.07 (−0.01 to 0.15)	0.08
eGFR MDRD186 (1 mL/min/1.73 m^2)			−0.02 (−0.05 to 0.01)	0.23

Data are expressed as estimate of fixed effects (b), 95% confidence interval, and P value.