Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK

Figure 6

The effects of propofol (50 M) on Bax, Bcl-2, Caspase3, Sur2b, Kir6.1, JNK, p-JNK, mTOR, and p-mTOR expression in HBVSMC. (a)–(f), (g), and (i) represent the levels of Bax, Bcl-2, Caspase3, Sur2b, Kir6.1, JNK, p-JNK, mTOR, and p-mTOR which were determined by western blotting and Tubulin was used as positive control. (h) and (j) show the ratio of p-JNK/JNK and p-mTOR/mTOR, respectively. HBVSMC cells were either not treated (control) or treated with propofol (50 μM) or propofol (50 μM) combined with SP600125 (Sp)/Everolimus (Ever.). Mean ± SD, . , versus control; , versus H/R group without drugs.

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