AMP-Activated Protein Kinase Attenuates High Salt-Induced Activation of Epithelial Sodium Channels (ENaC) in Human Umbilical Vein Endothelial Cells

Figure 5

High salt-induced increase in ENaC activity was blunted by metformin. ((a)–(d)) Representative traces of ENaC single-channel current recorded from HUVECs under indicated experimental conditions. (e) Summarized obtained from the single-channel recordings as shown in ((a)–(d)). The data showed that metformin significantly reduced ENaC compared to that from high NaCl group ( in each group). indicates versus control group; ## represents versus high NaCl group.