Table 1: Differential expression of genes related to Cys and CySS transporters and glutathione-related thiol-disulfide enzymes.

GeneOld versus young
(fold-difference)
Step-up
value

Cys and CySS transporters
Slc7a11Down 5.0-fold0.0034
Slc7a90.28
Slc1a10.85
Slc1a4Down 1.5-fold0.034
Slc1a50.092
Slc3a10.38
Slc3a20.69

Thiol-disulfide enzymes: Glutathione-related
Gpx1Up 1.4-fold0.033
Gpx20.096
Gpx30.49
Gpx40.064
Gpx50.87
Gpx60.71
Gpx70.067
Gpx80.23
Gsr0.54
Gclc0.62
Gclm0.60
Gss0.48
GlrxDown 1.7-fold0.0097
Glrx20.11
Glrx3Up 1.4-fold0.044
Glrx5Up 1.2-fold0.048

Fold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference. Those exceeding the cut-off threshold of 2-fold are shown in bold.
Step-up false discovery rate for the comparison between young and old cells following correction for multiple comparisons.