Functional Interactions between BK_Caα-Subunit and Annexin A5: Implications in Apoptosis

Table 2

Normalized current () at 60 mV and Va₅₀ values for channel of the control, ANXA5 siRNA knockdown, and ANXA5 overexpression models.

	Control ( = 8)		⁢ANXA5 siRNA knockdown ( = 8)		⁢ANXA5 overexpression ( = 8)
	at +60 mV	Va50 (mV)	at +60 mV	Va50 (mV)	at +60 mV	Va50 (mV)
[Ca^2+] 300 nM	0.25 ± 0.07	74.5 ± 4.6	0.38 ± 0.07	67.5 ± 2.8	0.19 ± 0.05	79.5 ± 3.8
CORM-2 30 μM	0.61 ± 0.1	55.9 ± 5.2	0.79 ± 0.06	44.1 ± 2.7	0.51 ± 0.06	57.5 ± 2.5
Ca^2+ 1 µM	0.44 ± 0.08	60.0 ± 3.9	0.58 ± 0.10	54.8 ± 6.3	0.28 ± 0.03	73.2 ± 2.7

The values were considered as significantly different from the respective values of ANXA5 siRNA knockdown ( > 0.05).