Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer

Table 1

Drugs targeted to decrease ROS.

Drugs	Targeted strategy	Mechanism	Reference
N-Acetyl-L-cysteine	Antioxidant agent	Scavenging ROS to inhibit proliferation and invasion	[53]
Anti-Duox2 monoclonal antibody	Nox suppressor	Neutralizing Nox isoenzyme to decrease ROS production	[54]
Longikaurin E	ROS-related pathway blocker	Inhibiting p38-MAPK and PI3K/Akt pathway to induce apoptosis	[55]
Nexrutine	ROS-related pathway blocker	Inhibiting STAT3/LC3/ROS	[56]
ACEI	Stromal cell inactivator	Decreasing ROS in PSC to inhibit pancreatic fibrosis	[57]
α-Mangostin	Stromal cell inactivator	Inhibiting ROS-induced PSC activation to attenuate pancreatic cancer cell invasion	[31]