Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy

Table 1

Drugs targeting specific CSCs and their modes of action.

Compounds	Mechanism of action	Type of CSCs	References
Temozolomide (TMZ)	Reversal of EMT and chemosensitizing CSCs	Glioblastoma	[27]
STA-4783	Targets OS by Hsp70 induction and induces ROS within CCs	Breast	[28]
Geldanamycin	Inhibition of the TRAP1 chaperone function	Breast, lung, and neural	[31]
Rottlerin (ROT)	Inhibitor of PI3K/Akt/mTOR pathway and inducer of apoptosis	Pancreatic	[33]
Bardoxolone methyl	Nrf2 inhibitor	Leukemia	[34]
Resveratrol	Wnt inhibitor	Breast	[35]
Honokiol	Notch inhibitor	Melanoma	[36]
Chloroquine (CQ)	Autophagy inducer	Colorectal	[37]
Pemetrexed	Folate antagonist	Lung	[38]
Melatonin	Induces autophagy by increasing ROS	Glioma	[39]
Salinomycin	K+-ionophore and triggers autophagy	General CSCs	[40]
BMD188	Proapoptotic	Prostate cancer	[41]
Gossypol	Hsp70 induction, ROS induction	Breast, leukemia	[42]
PUFAs	Induces apoptosis and autophagy	Colorectal	[43]
TrxR	ROS scavenger	Cervical	[44]