Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation

Figure 6

Effect of polydatin (PD) on the SIRT1-p53 signaling pathway. (1) p53 transcription nonindependent signaling pathway; (2) p53 transcription-independent signaling pathway. PD is likely to activate SIRT1, leading to inhibition of the p53 transcription nonindependent signaling pathway and mitochondrial-mediated apoptosis. SIRT1, silent information regulator 1.