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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 1737185, 15 pages
http://dx.doi.org/10.1155/2016/1737185
Research Article

Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation

1Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
2Guangdong Key Lab of Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China
3Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China

Received 12 November 2015; Revised 13 January 2016; Accepted 26 January 2016

Academic Editor: Reiko Matsui

Copyright © 2016 Zhenhua Zeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Nash, A. Hafeez, and S. Hou, “Hospital-acquired renal insufficiency,” American Journal of Kidney Diseases, vol. 39, no. 5, pp. 930–936, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Tran, D. Tam, A. Bardia et al., “PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice,” The Journal of Clinical Investigation, vol. 121, no. 10, pp. 4003–4014, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. R. H. Houtkooper, E. Pirinen, and J. Auwerx, “Sirtuins as regulators of metabolism and healthspan,” Nature Reviews Molecular Cell Biology, vol. 13, no. 4, pp. 225–238, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Vaziri, S. K. Dessain, E. E. Ng et al., “hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase,” Cell, vol. 107, pp. 149–159, 2001. View at Google Scholar
  5. J. Luo, A. Y. Nikolaev, S.-I. Imai et al., “Negative control of p53 by Sir2α promotes cell survival under stress,” Cell, vol. 107, no. 2, pp. 137–148, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Langley, M. Pearson, M. Faretta et al., “Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence,” The EMBO Journal, vol. 21, no. 10, pp. 2383–2396, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. K. T. Howitz, K. J. Bitterman, H. Y. Cohen et al., “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan,” Nature, vol. 425, no. 6954, pp. 191–196, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Giovannini, M. Migliori, B. M. Longoni et al., “Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys,” Journal of Cardiovascular Pharmacology, vol. 37, no. 3, pp. 262–270, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. D. H. Kim, Y. J. Jung, J. E. Lee et al., “SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53,” The American Journal of Physiology—Renal Physiology, vol. 301, no. 2, pp. F427–F435, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Zhang, Y. Feng, S. Qu et al., “Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53,” Cardiovascular Research, vol. 90, no. 3, pp. 538–545, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Sheng, Y.-H. Yu, K.-S. Zhao, W. Qin, and C.-H. Wang, “Hypotensive resuscitation combined with polydatin improve microcirculation and survival in a rabbit model of uncontrolled hemorrhagic shock in pregnancy,” Journal of Surgical Research, vol. 168, no. 1, pp. 103–110, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Miao, S. Wang, S. Miao, J. Wang, Y. Xie, and Q. Yang, “Cardioprotective effect of polydatin against ischemia/reperfusion injury: roles of protein kinase C and mito KATP activation,” Phytomedicine, vol. 19, no. 1, pp. 8–12, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. X.-H. Li, X. Gong, L. Zhang et al., “Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1,” Mediators of Inflammation, vol. 2013, Article ID 354087, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Wang, R. Song, H. N. Bian, U. T. Brunk, M. Zhao, and K.-S. Zhao, “Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 302, no. 7, pp. R805–R814, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. X. Wang, R. Song, Y. Chen, M. Zhao, and K.-S. Zhao, “Polydatin—a new mitochondria protector for acute severe hemorrhagic shock treatment,” Expert Opinion on Investigational Drugs, vol. 22, no. 2, pp. 169–179, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Li, X. Wang, M. Zhao, R. Song, and K. Zhao, “Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway,” Expert Opinion on Therapeutic Targets, vol. 19, no. 7, pp. 997–1010, 2015. View at Publisher · View at Google Scholar
  17. Z. Zeng, Z. Chen, S. Xu, R. Song, H. Yang, and K. Zhao, “Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator,” Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 965961, 12 pages, 2015. View at Publisher · View at Google Scholar
  18. L. Yu, Y. Sun, L. Cheng et al., “Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1,” Journal of Pineal Research, vol. 57, pp. 228–238, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Nakanishi, A. Fukushi, M. Sato et al., “Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture,” Molecular Pharmaceutics, vol. 8, no. 6, pp. 2142–2150, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Weiland, H. J. Ahr, H. W. Vohr, and H. Ellinger-Ziegelbauer, “Characterization of primary rat proximal tubular cells by gene expression analysis,” Toxicology in Vitro, vol. 21, no. 3, pp. 466–491, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. P. M. Mattila, Y. A. Nietosvaara, J. K. Ustinov, R. L. Renkonen, and P. J. Hayry, “Antigen expression in different parenchymal cell types of rat kidney and heart,” Kidney International, vol. 36, no. 2, pp. 228–233, 1989. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Gao, Z. Zeng, T. Li et al., “Polydatin inhibits mitochondrial dysfunction in the renal tubular epithelial cells of a rat model of sepsis-induced acute kidney injury,” Anesthesia & Analgesia, vol. 121, no. 5, pp. 1251–1260, 2015. View at Publisher · View at Google Scholar
  23. U. H. Beier, L. Wang, R. Han, T. Akimova, Y. Liu, and W. W. Hancock, “Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms,” Science Signaling, vol. 59, article ra45, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Shimizu, D. Bolati, A. Adijiang et al., “Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate,” American Journal of Physiology—Cell Physiology, vol. 299, no. 5, pp. C1110–C1117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. K. J. Kelly, Z. Plotkin, S. L. Vulgamott, and P. C. Dagher, “P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor,” Journal of the American Society of Nephrology, vol. 14, no. 1, pp. 128–138, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. B. K. McLaren, P. L. Zhang, and G. A. Herrera, “P53 protein is a reliable marker in identification of renal tubular injury,” Applied Immunohistochemistry & Molecular Morphology, vol. 12, no. 3, pp. 225–229, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. A. V. Vaseva and U. M. Moll, “The mitochondrial p53 pathway,” Biochimica et Biophysica Acta (BBA)—Bioenergetics, vol. 1787, no. 5, pp. 414–420, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Erster, M. Mihara, R. H. Kim, O. Petrenko, and U. M. Moll, “In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation,” Molecular and Cellular Biology, vol. 24, no. 15, pp. 6728–6741, 2004. View at Publisher · View at Google Scholar · View at Scopus