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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 1783728, 5 pages
http://dx.doi.org/10.1155/2016/1783728
Research Article

Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass

1Cardiovascular Surgery, Elazığ Medikal Park Hospital, 23 000 Elazığ, Turkey
2Health High School and Physiotherapy and Rehabilitation Department, Bitlis Eren University, 13 000 Bitlis, Turkey
3Department of Biochemistry, Fırat University Faculty of Veterinary Science, 23 000 Elazığ, Turkey
4Biochemistry, Elazığ Medikal Park Hospital, 23 000 Elazığ, Turkey

Received 29 June 2016; Revised 7 November 2016; Accepted 29 November 2016

Academic Editor: Neelam Khaper

Copyright © 2016 Fevzi Sarper Türker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods. Methods. A total of three consecutive arterial blood samples were obtained from the patients in the study group, in preoperative, early postoperative, and postoperative periods, respectively. Oxidative damage indicator (MDA) and antioxidant indicators (GPx, GSH, CAT, and SOD) were examined. Results. A statistically significant increase was observed in MDA level in postoperative period compared to preoperative and early postoperative periods. GSH levels and CAT activities increased significantly in early postoperative and postoperative periods. Analyses revealed an increase in GPx and SOD enzyme activities only in the postoperative period. Conclusion. Even though the increase in MDA level was suppressed by the increased GSH level and CAT activity like in early postoperative period, efficiency can be brought for the increases in insufficient significant antioxidant parameters in postoperative period by administering antioxidant supplements to the patients and thus the increase in MDA in postoperative period can be significantly suppressed.