Research Article

Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK–NF-κB Signaling Cascade: Protective Effects of Apocynin

Figure 1

Effects of HOCl-alb on ICAM-1 expression in HUVECs. HUVECs were stimulated with the indicated concentrations of HOCl-alb or 200 mg/L unmodified Alb for the indicated times, and then their ICAM-1 protein and mRNA expression were analyzed. HOCl-alb treatment increased ICAM-1 expression at both the protein (a, b, c) and mRNA levels (d, e) in a dose- and time-dependent manner. Data are expressed as the means ± SD of three independent experiments. ANOVA, in (a), (b), (d), (e); versus the control (b, e) or 0 h (a, d).