Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression

<div>Effect of carvedilol and vitamin C on the myocardial muscle NF-κB expression in azithromycin-injected rats. (a) Control showing negative (−) staining for NF-κB; (b) azithromycin-treated rats showing marked (+++) NF-κB positivity; (c) carvedilol + azithromycin-treated rats showing negative (−) NF-κB positivity; (d) vitamin C + azithromycin-treated rats showing moderate (++) NF-κB positivity (sections are immunohistochemically stained ×20).</div>

Oxidative Medicine and Cellular Longevity

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Figure 10

Figure 10: Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression

Figure 10 | Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression 