Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression

<div>Effect of carvedilol and vitamin C on the myocardial muscle caspase-3 expression determined in azithromycin-injected rats. (a) Control showing negative (−) staining for caspase-3; (b) azithromycin-treated rats showing marked (+++) caspase-3 positivity; (c) carvedilol + azithromycin-treated rats showing moderate (++) caspase-3 positivity; (d) vitamin C + azithromycin-treated rats showing mild (±) caspase-3 positivity (sections are immunohistochemically stained ×20).</div>

Oxidative Medicine and Cellular Longevity

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Figure 9

Figure 9: Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression

Figure 9 | Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression 