Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression

Table 3

Effect of carvedilol and vitamin C on cardiac muscle glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) enzyme activity measured in azithromycin-treated rats.

Groups	GPx; (U/g tissue)	SOD; (U/g tissue)	CAT; (U/g tissue)
Control	278 ± 73	881 ± 339	0.26 ± 0.09
Azithromycin	142 ± 65	409 ± 229	0.26 ± 0.07
Carvedilol + azithromycin	376 ± 147	319 ± 206	0.32 ± 0.19
Vitamin C + azithromycin	262 ± 63	774 ± 202	0.20 ± 0.13

Data are presented as mean ± SDM ().
Significant versus control (p ≤ 0.05).
Significant versus azithromycin ( ≤ 0.05).