Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications

Figure 2

Potential therapeutic use of H₂O₂ to fight lung cancer. H₂O₂ can decrease the proliferation and increase the apoptosis of lung cancer cells. In addition, metastasis may be prevented because of the inhibitory effects of H₂O₂ in cell migration and invasion. Artificial ROS-H₂O₂ production directed to cancer cells in an excessive manner may lead also to cell death. H₂O₂ may also increase the cytotoxicity of anticancer drugs and revert drug resistance, as well as potentiating the effect of repositioned drugs with anticancer effects.