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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 1947819, 15 pages
Research Article

Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice

Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China

Received 30 May 2016; Accepted 4 August 2016

Academic Editor: Ciprian Tomuleasa

Copyright © 2016 Jiaming Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Molecular hydrogen () has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the last time of radiation exposure, all the mice were employed for the determination of the body mass (BM) observation, forced swim test (FST), the open field test (OFT), the chromosome aberration (CA), the peripheral blood cells parameters analysis, the sperm abnormality (SA), the lymphocyte transformation test (LTT), and the histopathological studies. And significant differences between the treatment group and the radiation-only groups were observed, showing that could diminish the detriment induced by LDLTR and suggesting the protective efficacy of in multiple systems in mice against LDLTR.