The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

Figure 1

Schematic representation of Nrf2 and Keap1 structures. (a) Nrf2 contains seven domains, Neh1–Neh7. The Neh2 domain contains two binding motifs, DLG and ETGE, responsible for the interaction with Keap1. The Neh4, Neh5, and Neh3 domains are important for the transactivation activity of Nrf2. The Neh7 domain is critical for RXRα binding. The Neh6 domain regulates Nrf2 degradation by β-TrCP1. The Neh1 domain has a basic region leucine zipper motif for DNA binding. (b) Keap1 contains three major domains. The BTB domain mediates Keap1 homodimerisation and the IVR domain contains critical cysteine residues and together they associate with Cul3. The Kelch/DGR domain mediates the binding with the Neh2 domain of Nrf2.

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