The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

Table 1

Genes regulated by Nrf2 in mice and humans.

Symbol	Name	Species	References
Antioxidant genes
GCLC	Glutamate-cysteine ligase, catalytic subunit	m, h	[188, 189]
GCLM	Glutamate-cysteine ligase, modifier subunit	m, h	[188, 189]
GLRX	Glutaredoxin 1	h	[190]
GPX2	Glutathione peroxidase 2	m, h	[190, 191]
GPX4	Glutathione peroxidase 4	m	[16]
GSR1	Glutathione reductase	m, h	[188, 190]
SLC6A9	Glycine transporter	m	[16]
SLC7A11	Cysteine/glutamate transporter	m, h	[16, 188]
PRDX1-6	Peroxiredoxins 1 and 6	m, h	[10, 16]
SRXN1	Sulfiredoxin-1	m, h	[11, 188]
TXN1	Thioredoxin	m, h	[10, 16]
TXNRD1	Thioredoxin reductase 1	m, h	[188, 190]
HO-1-related genes
HMOX1	Heme oxygenase 1	m, h	[10, 188]
BLVRA	Biliverdin reductase A	h	[190]
BLVRB	Biliverdin reductase B	m, h	[16, 190]
FECH	Ferrochelatase	h	[188]
FTH1	Ferritin, heavy polypeptide 1	m, h	[10]
FTHL12-17	Ferritin, heavy polypeptides 12 and 17	h	[188, 190]
FTL1	Ferritin, light polypeptide	m, h	[188, 190]
Detoxifying enzymes
NQO1	NAD(P)H:quinone oxidoreductase 1	m, h	[188, 190]
GSTA1	Glutathione S-transferase class Alpha 1	m	[192]
GSTM1	Glutathione S-transferase class Mu 1	m	[192]
GSTP1	Glutathione S-transferase class Pi 1	m	[12]
UGT1A1	UDP glucuronosyl-; transferase 1 family	h	[190]
UGT2B7	UDP glucuronosyl-; transferase 2 family	m, h	[16, 190]
Drug transporters
ABCB6	ATP-binding cassette, subfamily B(MDR/TAP)	m, h	[10, 11]
ABCC1	ATP-binding cassette, subfamily C(CFTR/MRP)	m	[193]
ABCC2	ATP-binding cassette, subfamily C(CFTR/MRP)	m, h	[193]
ABCC3	ATP-binding cassette, subfamily C(CFTR/MRP)	m, h	[193]
ABCC4	ATP-binding cassette, subfamily C(CFTR/MRP)	m	[193]
ABCC5	ATP-binding cassette, subfamily C(CFTR/MRP)	m	[194]