Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy

Figure 3

Glycemic profile. Fasting glucose (mgdL⁻¹) at three different points (basal fasting glucose: Time 0; beginning of pharmacological intervention with tempol (50 mgkg⁻¹) and apocynin (50 mgkg⁻¹): Time 1; and the end of pharmacological intervention: Time 2) and end time of fasting glucose in young (a) and old (b) C57BL/6 mice. Evaluation of glucose tolerance and Area under the curve of the test (AUC) in young (c) and old (d) C57BL/6 mice. Evaluation of insulin sensitivity and area under the curve of the test (AUC) in young (e) and old (f) C57BL/6 mice. CT = control group; HF = high fat diet group; HFT = high fat diet + tempol group; HFA = high fat diet + apocynin group. Each point of the graph represents the mean ± SEM. ANOVA (two-way) with Bonferroni’s post hoc test: ; ; , CT versus HF; ; , HFT versus HF; ; ; , HFA versus HF. Each bar graph represents the mean ± SEM. ANOVA (one-way) with Bonferroni’s post hoc test: ; ; , CT versus HF; ; , HFT versus HF; , HFA versus HF ( = 5-6).

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