Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy
Table 1
Intake and biometric parameters from young and old C57BL/6 mice after pharmacological intervention with tempol (50 mg⋅kg−1) and apocynin (50 mg⋅kg−1).
Intake and biometric parameters
Young mice
Old mice
CT-Y
HF-Y
HFT-Y
HFA-Y
CT-O
HF-O
HFT-O
HFA-O
Food intake (g/mouse/body weight)
0.15 ± 0.005
0.07 ± 0.003
0.06 ± 0.003
0.07 ± 0.003
0.13 ± 0.006
0.05 ± 0.003
0.06 ± 0.003
0.05 ± 0.004
Right tibia (cm)
1.62 ± 0.01
1.59 ± 0.01
1.59 ± 0.01
1.58 ± 0.02
1.66 ± 0.01
1.64 ± 0.01
1.64 ± 0.01
1.61 ± 0.01
Cephalocaudal length (cm)
17.56 ± 0.23
17.27 ± 0.19
16.88 ± 0.15
17.23 ± 0.16
18.39 ± 0.15
18.58 ± 0.13
18.49 ± 0.18
18.58 ± 0.30
Abdominal circumference (cm)
9.36 ± 0.40
9.47 ± 0.20
8.55 ± 0.05
8.23 ± 0.44
8.65 ± 0.16
10.48 ± 0.31
10.26 ± 0.29
10.41 ± 0.38
Epididymal fat weight (%)
0.62 ± 0.07
3.36 ± 0.52
3.83 ± 0.40
3.62 ± 0.84
1.09 ± 0.10
3.79 ± 0.26
3.77 ± 0.38
3.72 ± 0.30
Perirenal fat weight (%)
0.18 ± 0.02
1.54 ± 0.26
1.70 ± 0.20
1.38 ± 0.38
0.49 ± 0.06
2.55 ± 0.24
2.54 ± 0.28
2.73 ± 0.23
Mesenteric fat weight (%)
1.55 ± 0.10
2.10 ± 0.3
2.44 ± 0.21
2.49 ± 0.26
1.78 ± 0.09
3.25 ± 0.29
3.82 ± 0.31
3.57 ± 0.23
Gastrocnemius (g)/tibial length (mm)
0.010 ± 0.00
0.009 ± 0.00
0.009 ± 0.00
0.01 ± 0.00
0.010 ± 0.00
0.01 ± 0.00
0.009 ± 0.00
0.01 ± 0.00
Heart (g)/tibial length (mm)
0.009 ± 0.00
0.008 ± 0.00
0.007 ± 0.00
0.008 ± 0.00
0.009 ± 0.00
0.009 ± 0.00
0.009 ± 0.00
0.01 ± 0.00
Intestine (g)/tibial length (mm)
0.073 ± 0.00
0.046 ± 0.00
0.040 ± 0.00
0.053 ± 0.00
0.071 ± 0.00
0.050 ± 0.00
0.046 ± 0.00
0.036 ± 0.00
Y = young; O = old; CT = control group; HF = high fat diet group; HFT = high fat diet + tempol group; HFA = high fat diet + apocynin group. Values represent the mean ± SEM. ANOVA (one-way) with Bonferroni’s post hoc test: , HF versus CT; , HFT versus HF; , HFA versus HF. .
