Green Tea Polyphenols Attenuated Glutamate Excitotoxicity via Antioxidative and Antiapoptotic Pathway in the Primary Cultured Cortical Neurons

Figure 3

TP reduced oxidative stress induced by glutamate in the neurons. (a) Bar graphs show that glutamate induced ROS release in the primary cultured cortical neurons was prevented by incubation of TP. (b) Bar graphs show that the SOD activity in the neurons was downregulated by the glutamate, while TP treatment rescued the SOD activity. Two independent experiments were performed. Data shown represent one experiment. /group. One-way analysis of variance (ANOVA) followed by Tukey post hoc multiple comparisons tests, for (a); for (b). compared to the control group and compared to the Glu group.

(a)

(b)