Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3β Phosphorylation
Formononetin protected cardiomyocyte H9c2 cells against OGD/reoxygenation injury. (a) Chemical structure of formononetin. (b) Effect of formononetin on the cell viability of H9c2 cells under normal or OGD/reoxygenation condition. H9c2 cells were treated with formononetin at various concentrations either under normal condition for 24 h (Normal) or subjected to OGD for 8 h followed by reoxygenation for 16 h (OGD/R). The cell viability was determined by MTT assay. The values represent mean ± SD (). (OGD/R versus Normal); (drug versus OGD/R).