Serum from Varicose Patients Induces Senescence-Related Dysfunction of Vascular Endothelium Generating Local and Systemic Proinflammatory Conditions

Table 1

Characteristics of patients with varicose veins and the control individuals from whom serum samples were taken.

Parameter	Varicose patients	Healthy donors
	40	40
Sex (male/female; )	15/25	17/23
Age (mean ± SD/ range; y)	52 ± 15/21–81	51 ± 15/17–77
	Comorbidities (number)
No comorbidities	23	29
Hypertension	6	6
Hypothyroidism	2	0
Asthma	2	0
Obesity	2	2
Psoriasis	3	1
Allergy	1	2
Adrenal insufficiency	1	0

Comorbidities have been treated as follows: hypertension: angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers; hypothyroidism: synthetic analogue of thyroxine; asthma: inhaled sympathomimetic drugs; allergy: antihistamine drugs; adrenal insufficiency: hormone of the adrenal cortex.