t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway
t-BHQ promotes Nrf2 nuclear translocation but does not induce Nrf2 transcription in the hippocampus and frontal cortex. (a) Nrf2 mRNA level was quantified by RT-PCR and the appropriate dose of PbAc (60 mg/kg) was chosen in this experiment. in each group. (b and c) Nuclear protein was isolated and applied in Western blot experiment (b) and EMSA experiment (c). Nrf2-ARE binding activity and the content of Nrf2 in nucleus were detected and the immunoblots were quantified. in each group. Data represent the mean ± SEM of the results. represents significant differences compared with the control group.
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