t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway

Figure 3

t-BHQ upregulates the expression of Nrf2 downstream targets in the hippocampus and frontal cortex. Rats were pretreated with t-BHQ or corn oil and then subjected to PbAc exposure (60 mg/kg). The levels of mRNAs and protein were examined by RT-PCR and Western blot, respectively. The mRNA of GCLC, HO-1, and NQO1 (a) and the protein levels of HO-1 and NQO1 (b) were analyzed in both the hippocampus and frontal cortex. in each group. Data represent the mean ± SEM of the results. , , and represent significant differences compared with the control group. and represent significant differences between two groups with or without t-BHQ treatment at the same concentration of PbAc (60 mg/kg).

(a)

(b)