t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway

Figure 6

t-BHQ confers protection against PbAc-induced oxidative stress and apoptosis. The SH-SY5Y cells were pretreated with t-BHQ (40 μM) or DMSO for 12 h, followed by PbAc exposure (25 μM) for 24 h. Cell viability (a), caspase 3/7 activity (b), ROS production (c), GSH content (d), and apoptotic related proteins of Bcl2, Bax, and Bcl-xl (e) were analyzed. All data represent the mean ± SEM of the results. , , and represent significant differences.

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