Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation

Figure 2

Hippocampal melatonin under REMSD. Bars express means ± standard deviation. Statistical analysis showed significant differences between groups: control group versus LZD + MEL + REMSD; only REM sleep deprivation and LZD + REMSD () Mann-Whitney test. Furthermore, the MEL + REMSD group revealed a higher concentration of melatonin in comparison to the control, REMSD, LZD + MEL + REMSD, and LZD + REMSD groups (); Mann-Whitney test. REMSD: REM sleep deprivation, MEL: melatonin, and LZD: luzindole.